Passiflora incarnata has been used in North American and European herbal traditions for restlessness, mild nervous tension, and sleep difficulty. EMA recognizes preparations of the aerial parts for relief of mild symptoms of mental stress and to aid sleep on the basis of longstanding use, not strong clinical proof. NCCIH likewise notes that research in people is limited.

Passionflower's intricate radial flower gave Christian missionaries a visual language for symbols of the Passion, while contemporary magical practice often reads its winding tendrils and striking bloom as emblems of surrender, calm, dreams, and trust. The approved source emphasizes tranquility, emotional healing, intuition, and spiritual protection. Correctly identified dried material may be kept in a sealed dream pillow or charm bag, or its image used during quiet reflection and release work.